Syphilis Treatment Guide for Doctors

Recommended Regimens

Primary, secondary, early latent, less than one year duration:

  • Benzathine penicillin G 2.4 million U IM in a single session

Late latent more than one year of indeterminate duration:

  • Benzathine penicillin G 2.4 million U IM once a week for three successive weeks (total dose 7.2 million U)

Call the Sexual Health Centre to obtain Benzathine penicillin G.

During Pregnancy

Same as recommended treatment regimen. If a pregnant woman is treated with anything other than Benzathine penicillin G or is treated in the last month of pregnancy, the baby must be treated after birth.

Penicillin Allergy

Desensitization and use of penicillin preferred.

Primary, secondary, early latent

  • Docycline 100 mg orally bid for 14 days

Late latent


For primary, secondary, early latent

  • repeat serology one, three, six, 12 and 24 months after treatment

For late latent

  • repeat serology 12 and 24 months after treatment

Partner Testing

Refer to the Canadian Sexually Transmitted Infections Guidelines.


Free treatment for reportable Sexually Transmitted Infections are available from our Sexual Health Centres.

¹ Pichichero, M.E., 2005, A review of evidence supporting the American academy of pediatrics recommendation for prescribing cephalosporin antibiotics. American Academy of Pediatrics. 115(4), 1048-1057. Anti-infective guidelines for community acquired infections, 2010.

Page Feedback Did you find what you were looking for today?